Pepsin, enzyme-ka xoogga leh ee ku jira casiirka gastric kaas oo shiidaya borotiinnada sida kuwa hilibka, ukunta, miraha, ama waxyaabaha caanaha laga sameeyo.Pepsin waa qaabka firfircoon ee baaluq ee zymogen (protein aan firfircoonayn) pepsinogen.

PepsinWaxaa markii ugu horreysay aqoonsaday 1836-kii cilmi-nafsiga Jarmalka Theodor Schwann.Sannadkii 1929-kii, kicintiisa iyo dabeecadda borotiinka waxaa soo sheegay biochemist Mareykan ah John Howard Northrop oo ka tirsan Machadka Rockefeller ee Cilmi-baarista Caafimaadka.(Northrop ka dib wuxuu helay qayb ka mid ah 1946 Nobel Prize for Chemistry shaqadiisa si guul leh u nadiifinta iyo nadiifinta enzymes.)

Qanjidhada ku jira xuubka xabka ee caloosha ayaa sameeya oo kaydiya pepsinogen.Dareenka ka imanaya Dareemaha xididdada dhiigga iyo dheecaannada hormoonnada ee gastrin iyo secretin waxay kiciyaan sii deynta pepsinogen ee caloosha, halkaas oo lagu qaso hydrochloric acid oo si degdeg ah loogu beddelo pepsin enzyme firfircoon.Awoodda dheefshiidka ee pepsin ayaa ugu weyn aashitada casiir gastric ee caadiga ah (pH 1.5-2.5).Mindhicirka dhexdiisa asiidhyada gastric waa dhexdhexaad (pH 7), iyo pepsin hadda waxtar ma laha.

Marka la eego habka dheef-shiidka, pepsin-ku wuxuu saameeyaa qayb yar oo borotiinada ah oo loo yaqaan 'peptides', ka dibna ama laga soo nuugo mindhicirka oo gala dhiigga ama ay sii jajabiyaan enzymes pancreatic.

Qadar yar oo pepsin ah ayaa caloosha uga soo gudba qulqulka dhiigga, halkaasoo ay jebiso qaar ka mid ah kuwa waaweyn, ama aan weli la dheefshiidin, jajabyada borotiinka oo laga yaabo in uu nuugay xiidmaha yar.

Dib-u-soo-laabashada daba-dheeraada ee pepsin, acid, iyo walxaha kale ee caloosha ka soo gala hunguriga hunguriga waxay aasaas u yihiin xaaladaha reflux, gaar ahaan cudurka gastroesophageal reflux iyo laryngopharyngeal reflux (ama reflux extraesophageal).Midda dambe, pepsin iyo acid waxay u socdaalaan ilaa larynx, halkaas oo ay waxyeello u geysan karaan xuubka laryngeal oo ay soo saaraan calaamado u dhexeeya xabeeb iyo qufac daba-dheer ilaa laryngospasm (xannuun aan ikhtiyaari ahayn ee xadhkaha codka) iyo kansarka laryngeal.

Deebiyo'pepsinwaxa laga soosaaray xabka gastric porcine tayo sare leh anagoo adeegsanayna tignoolajiyada soosaarida gaarka ah.Waxaa si weyn loogu isticmaalaa dyspepsia-ka oo ay keento qaadashada cuntooyinka borotiinka ah. dheefshiidka hypofunction ee xilliga soo kabashada iyo la'aanta borotiinka caloosha oo ay keento gastritis atrophic dabadheeraad ah, kansarka gastric iyo dhiig-yarida malignant.

Iyadoo ilaa 30 sano ee sahaminta cilmi-baarista sayniska iyo dhaqanka warshadaha, Waxaan aasaasay a gaar ah "DEEBIO 3H Technology", isticmaalaya habka oo dhan ilaalinta enzymatic.The technology gacanta muhiimka ah, iyada oo firfircoonaan aan burburin, toosin zymogen ah, iyo garwaaqsado firfircooni sare, nadiif sare iyo xasilloonida sare ee alaabta bio-enzyme.

Ku soo dhawoow inaad nala soo xiriirto, waxaan rajeyneynaa inaan kula xiriirno oo aan si daacad ah u sugno su'aalahaaga